Adrenoceptor agonists inhibit calcium-dependent potentials in rat stellate ganglion neurons.
نویسندگان
چکیده
AIM To study the effects of adrenoceptor agonists on the stellate ganglion neurons. METHODS Intracellular recordings were made from neurons of the isolated rat stellate ganglia. RESULTS Noradrenaline and clonidine (10-30 mumol.L-1) reversibly depressed 3 types of calcium-dependent potentials, namely, the action potential shoulder; the spike after-hyperpolarization; the Ca2+ spike evoked in Krebs' solution containing TTX and TEA and fast excitatory postsynaptic potential (f-EPSP). CONCLUSION The adrenoceptor agonists inhibitied the 3 calcium-dependent potentials; f-EPSP was inhibited by reducing Ca2+ influx at presynaptic site in population of neurons.
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ورودعنوان ژورنال:
- Zhongguo yao li xue bao = Acta pharmacologica Sinica
دوره 18 2 شماره
صفحات -
تاریخ انتشار 1997